2020-06-01

Propofol is known to possess direct antiemetic effects. Its use for induction and maintenance of anaesthesia has been shown to be associated with a lower incidence of postoperative nausea and vomiting (PONV) when compared to any other anaesthetic drug or technique. However, its mechanism of action in this context is still not well understood. In this article, the best ways to take advantage of

A surprising number (62.5%) expect propofol to reduce PONV more than 60 min after induction dose. In addition 37% of those using propofol for its antiemetic effect use a "sandwich" technique. We report on the use of propofol in 35 patients. In 22 patients, propofol was used for palliative sedation when treatment with benzodiazepines had failed. The mean dose range during treatment was between 0.90 and 2.13mg/kg/h. The effect was assessed as good or very good in 91% of the patients. Antiemetic effect of propofol Antiemetic effect of propofol Montgomery, J.E.; Kf.Stin, I.G.; Sneyd, J.R. 1996-11-01 00:00:00 W.G. NOTCUTT I read with interest H.F. Seeleyâ s article (Anaesthesia 1996; 51: 571-4) on the causes and outcome of stress amongst anaesthetists.

(Anaesthesia 1996; 51: 554-7) dealing with infusions of subhypnotic doses of propofol for the prevention of postoperative nausea and vomiting. It is interesting to note that the authors found no differences between the infusions Antiemetic effect of propofol I read with interest the study of Montgomery et al. (Anaesthesia 1996; 51: 554-7) dealing with infusions of subhypnotic doses of propofol for the prevention of postoperative nausea and vomiting. It is interesting to note that the authors found no differences between the infusions Antiemetic effect of propofol administered at the end of surgery in laparoscopic assisted vaginal hysterectomy. Antiemetic effect of propofol administered at the end of surgery in laparoscopic assisted vaginal hysterectomy. BACKGROUND: Postoperative nausea and vomiting (PONV) commonly occur after general anesthesia, especially in women.

• Ondansetron. Overview of antiemetic medications. • Aprepitant – NK-1 receptor antagonist.

It has been proposed that propofol has antiemetic effects even in nonsedative doses. The aim of this study was to investigate whether propofol influences

Dec 23, 2004 Although the sedative–hypnotic effects of propofol and midazolam are known, their antiemetic effects in the treatment of PONV are not. Nov 12, 2015 Since antiemetic drugs have different sites of action, multi-modal treatment can be beneficial to prevent PONV in high-risk patients (Norred, 2003; May 26, 2020 antiemetic drug even if propofol infusion has proven to have antiemetic effect. We hypothesized that the addition of ondansetron prophylaxis antiemetics and total intravenous anesthesia on postoperative group (C). All patients were anesthetized using propofol and Effect of prophylactic antiemetic.

1996-10-01 · open archive. Postoperative nausea and vomiting (PONV) are unpleasant, often underestimated side effects of anaesthesia and surgery, not devoid of medical complications. Prevention with antiemetics is only partially effective. Propofol has been shown recently to possess antiemetic properties in several situations.

compared the antiemetic efficacy of thiopental (1.0 mg/kg) versus propofol (0.5 mg/kg) administered at the end of middle ear surgery, a procedure often associated with emetic sequelae[].The subhypnotic dose of propofol provided superior prophylaxis against retching and vomiting during the The exact mechanism by which propofol acts as an antiemetic remains unclear, but propofol is not considered to have vagolytic properties. 9 In addition, the efficacy of propofol as an antiemetic is not based on the lipid emulsion in the formulation of propofol. 12 Hammas et al 13 have evaluated the effect of propofol on nausea and vomiting induced by ipecacuanha known to release 5 2020-05-11 The effects of low dose propofol for prophylaxis of PONV were studied in 172 patients undergoing breast and abdominal surgery. Propofol prophylaxis was compared with a multidrug regimen consisting of dexamethasone and three antiemetic drugs, ondansetron, droperidol and metoclopramide. In order to investigate the putative anti-emetic effect of propofol, 53 patients undergoing gynaecological laparoscopy were given a standard anaesthetic including induction with thiopentone. At the 2020-06-01 Propofol is known to exert an antiemetic effect even though the exact mechanism is still unclear. One study reported that propofol reduces PONV by blocking the 5-hydroxy-tryptamin-3 receptor of the serotonergic system, 20 , 21 while others reported that inhibition of the chemoreceptor trigger zone and vagal nuclei, which are directly related to nausea and vomiting, is associated with the 2014-09-16 anaesthesia with propofol is associated with a lower incidence of PONV when compared with inhalational anaesthetic.

6 rows Post operative nausea and vomiting (PONV) remains one of the most common and distressing complications after surgery resulting in pain, hematoma and … Antiemetic effect of subhypnotic doses of propofol after thyroidectomy Postoperative nausea and vomiting (PONV) are unpleasant, often underestimated side effects of anaesthesia and surgery, not devoid of medical complications.
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It has been proposed that propofol has antiemetic effects even in nonsedative doses.

At the 2020-06-01 Propofol is known to exert an antiemetic effect even though the exact mechanism is still unclear. One study reported that propofol reduces PONV by blocking the 5-hydroxy-tryptamin-3 receptor of the serotonergic system, 20 , 21 while others reported that inhibition of the chemoreceptor trigger zone and vagal nuclei, which are directly related to nausea and vomiting, is associated with the 2014-09-16 anaesthesia with propofol is associated with a lower incidence of PONV when compared with inhalational anaesthetic. However, it is unclear regarding the dose response of propofol when used as an antiemetic, and how propofol should be administered in the perioperative period for its antiemetic effects. Antiemetic efficacy of propofol 257 same as described previously.8 9 Three different PONV outcomes were extracted in dichotomous form (i.e.
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The antiemetic properties of propofol were first demonstrated by Borgeat et al. and subsequently by several other authors. However, its precise mechanism of

Its use for induction and maintenance of anaesthesia has been shown to be associated with a lower incidence of postoperative nausea and vomiting (PONV) when compared to any other anaesthetic drug or technique. However, its mechanism of action in this context is still not well understood. Antiemetic effect of propofol. Borgeat A. Comment on Anaesthesia.

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It has been proposed that propofol has antiemetic effects even in nonsedative doses. The aim of this study was to investigate whether propofol influences vomiting induced by the dopamine agonist apomorphine.

Propofol antiemetic use for induction and maintenance of anesthesia has been shown to be associated with a lower incidence of postoperative nausea and vomiting (PONV) when compared to any other anesthetic drug or technique. Antiemetic effect of propofol administered at the end of surgery in laparoscopic assisted vaginal hysterectomy.